A question which arises is "what should I prepare for such a campaign". A 'normal' trader campaign requires a starmap, UWPs, some plot hooks and passengers/patrons; but this one would be a political sandbox, so things would be different.
I was thinking about making one or two important NPCs per world, contacts if you will; each would have his or her motivations and his or her interests. Other than that, detailing the governments of each world using both Path of Tears and the MGT Factions/Cultural Quirks tables would probably also be useful.
Any additional suggestions about what I should prep would be welcome.